HLF and TET2

Number of citations of the paper that reports this interaction (PubMedID 30404004)
16

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HLF	TET2
Description		HLF transcription factor, PAR bZIP family member	tet methylcytosine dioxygenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Response To Organic Cyclic Compound Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation
Pathways			TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Bipolar disorder ( 33263727 31043756) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Urate levels ( 31985003 31578528 23263486) Urate levels in obese individuals ( 25811787) Waist circumference ( 28552196) Weight ( 28552196) Zinc levels ( 26025379)	Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body shape index ( 34021172) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) Fasting insulin ( 33402679 34059833) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Response to esketamine in treatment resistant depression ( 32724131) Self-reported risk-taking behaviour ( 30271922) Serum alkaline phosphatase levels ( 33547301) Tonsillectomy ( 27182965 28928442) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Western dietary pattern ( 28644415)
Interacting Genes		11 interacting genes: ABCC3 ARNTL CCDC59 CREBBP DBP HNF4G MYB MYL4 PPAN TET2 USO1	19 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS72 ZCCHC14 ZNF207
Entrez ID		3131	54790
HPRD ID		00797	07876
Ensembl ID		ENSG00000108924	ENSG00000168769
Uniprot IDs		Q16534	A0A024RDF7 A0A158SIU0 Q6N021
PDB IDs			4NM6 5D9Y 5DEU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?