HLA-A and UBB

Number of citations of the paper that reports this interaction (PubMedID 14722266)
124

Data Source:
HPRD (in vivo)

		HLA-A	UBB
Description		major histocompatibility complex, class I, A	ubiquitin B
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Medial Cisterna Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex MHC Class I Peptide Loading Complex Recycling Endosome Membrane Extracellular Exosome Endoplasmic Reticulum Exit Site Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Endocytic Vesicle Membrane Vesicle Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	RNA Binding Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding CD8 Receptor Binding TAP Binding TAP Complex Binding	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of T Cell Cytokine Production Immune Response Detection Of Bacterium Antibacterial Humoral Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Interferon-gamma Production CD8-positive, Alpha-beta T Cell Activation Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Memory T Cell Activation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation	Male Meiosis I Female Meiosis I Female Gonad Development Protein Ubiquitination Modification-dependent Protein Catabolic Process Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Positive Regulation Of Protein Ubiquitination Mitochondrion Transport Along Microtubule Neuron Projection Morphogenesis Regulation Of Mitochondrial Membrane Potential Fat Pad Development Regulation Of Proteasomal Protein Catabolic Process Seminiferous Tubule Development Energy Homeostasis Regulation Of Neuron Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Monoubiquitination
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport Circadian Clock TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Maturation of protein E Maturation of protein E Inactivation of CSF3 (G-CSF) signaling Negative regulation of FLT3 FLT3 signaling by CBL mutants Regulation of BACH1 activity TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		3-Indolebutyric Acid Nelipepimut-S Nelipepimut-S Coccidioides immitis spherule Coccidioides immitis spherule	(4s)-5-Fluoro-L-Leucine
Diseases
GWAS		Adult body size ( 32376654) Adverse response to carbamazepine ( 21149285) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) C-peptide levels in type I diabetes ( 29404672) Carbamazepine-induced maculopapular exanthema ( 29288229) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide) ( 25813999) Chickenpox ( 28928442) Childhood ear infection ( 28928442) Chronotype ( 30696823) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) Drug-induced liver injury (flucloxacillin) ( 30661239) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Frontal fibrosing alopecia ( 30850646) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) HIV-1 control ( 20041166) IgA nephropathy ( 32912934 22197929) IgE levels ( 22075330) Immature fraction of reticulocytes ( 32888494) Late-onset myasthenia gravis ( 26562150) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 32888494) Mean reticulocyte volume ( 32888494) Menarche (age at onset) ( 25231870) Monocyte percentage of white cells ( 32888494) Mumps ( 28928442) Nasopharyngeal carcinoma ( 19664746 20512145) Plantar warts ( 28928442) Plateletcrit ( 32888494 27863252) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Setpoint viral load in HIV-1 infection ( 26553974) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 26606652 28714469) Type 1 diabetes (age at diagnosis) ( 33179336) Vitiligo ( 20410501 27723757) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321)
Interacting Genes		30 interacting genes: APLP2 B2M BCAP31 BUD31 CALR CANX CCR9 CD8A DEK DERL1 ERBB2 GPR35 KIR3DL2 LILRB1 LILRB2 LTB4R2 MAGEA1 MAGEA4 MEOX2 MEX3C PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17	81 interacting genes: APP ATXN3 BIRC2 BRAP BRCA1 CDC25A CDC34 CDIP1 CDKN1B CDT1 CDX2 CHEK1 DAZAP2 DESI1 DNMT1 DUSP1 ECT2 EGFR ELF4 EPS15 ERBB2 FANCD2 FSHR HDAC6 HGS HLA-A IKBKB IKBKG JUN LIG4 LYN MAPT MDM2 MTURN MYBL2 MYC NR3C1 NTRK1 NTRK2 OPTN PCNA PIN1 PLEKHB2 PLSCR4 POLI PRKN PSMD4 RABGEF1 RAD23A RAD23B RNF11 SDCBP SH3KBP1 SKP2 SMAD4 SMURF1 SNCA SNCAIP SQSTM1 STUB1 SYK TAX1BP1 TGFBR1 TP53 TRAF6 TRIM37 TRIM5 UBAC1 UBASH3A UBASH3B UBE2D2 UBE2K UBE2N UBE2S UBQLN1 UBQLN2 UIMC1 USP1 USP30 WWOX XIAP
Entrez ID		3105	7314
HPRD ID		00826	06771
Ensembl ID		ENSG00000206503	ENSG00000170315
Uniprot IDs		B1PKY1 B2R7U3 P04439 Q5SUL5	P0CG47 Q5U5U6
PDB IDs		1AKJ 1AO7 1AQD 1B0G 1B0R 1BD2 1DUY 1DUZ 1EEY 1EEZ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1JF1 1JHT 1LP9 1OGA 1P7Q 1Q94 1QEW 1QR1 1QRN 1QSE 1QSF 1QVO 1S8D 1S9W 1S9X 1S9Y 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UR7 1W72 1X7Q 2AV1 2AV7 2BCK 2BNQ 2BNR 2C7U 2CLR 2F53 2F54 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2HLA 2HN7 2J8U 2JCC 2P5E 2P5W 2PYE 2UWE 2V2W 2V2X 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2XPG 3BGM 3BH8 3BH9 3BHB 3BO8 3D25 3D39 3D3V 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HLA 3HPJ 3I6G 3I6K 3I6L 3IXA 3KLA 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MYJ 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3PWJ 3PWL 3PWN 3PWP 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3TO2 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VXM 3VXN 3VXO 3VXP 3VXR 3VXS 3VXU 3W0W 3WL9 3WLB 4E5X 4EMZ 4EN2 4EUP 4F7M 4F7P 4F7T 4FTV 4GKN 4GKS 4HWZ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4K7F 4L29 4L3C 4L3E 4MJ5 4MJ6 4MNQ 4N8V 4NNX 4NNY 4NO0 4NO2 4NO3 4NO5 4NQV 4NQX 4OV5 4QOK 4U6X 4U6Y 4UQ2 4UQ3 4WJ5 4WU5 4WU7 4WUU 5BRZ 5BS0 5C07 5C08 5C09 5C0A 5C0B 5C0C 5C0D 5C0E 5C0F 5C0G 5C0I 5C0J 5D2L 5D2N 5D9S 5DDH 5E00 5E6I 5E9D 5ENW 5EOT 5EU3 5EU4 5EU5 5EU6 5EUO 5F7D 5F9J 5FA3 5FA4 5FDW 5GRD 5GRG 5GSD 5HGA 5HGB 5HGD 5HGH 5HHM 5HHN 5HHO 5HHP 5HHQ 5HYJ 5IRO 5ISZ 5JHD 5JZI 5MEN 5MEO 5MEP 5MEQ 5MER 5N1Y 5N6B 5NHT 5NME 5NMF 5NMG 5NMH 5NMK 5NQK 5SWQ 5TEZ 5W1W 5WJL 5WJN 5WKF 5WKH 5WSH 5WWI 5WWJ 5WWU 5WXC 5WXD 5XOV 5YXN 5YXU 6AM5 6AMT 6AMU 6APN 6AT9 6D78 6D7G 6DKP 6EI2 6ENY 6EQA 6EQB 6EWA 6EWC 6EWO 6G3J 6G3K 6ID4 6J1W 6J29 6J2A 6JOZ 6JP3 6MPP 6NCA 6O9B 6O9C 6OPD 6PBH 6PTB 6PTE 6Q3K 6Q3S 6R2L 6RP9 6RPA 6RPB 6RSY 6SS7 6SS8 6SS9 6SSA	2KHW 2MBB 2MRO 2MSG 2N13 4UEL 4UF6 4WHV 4WLR 4WUR 4XOF 4ZFR 4ZFT 4ZPZ 4ZUX 5BNB 5CAW 5CRA 5CVM 5CVN 5CVO 5D0K 5D0M 5DFL 5DK8 5E6J 5EDV 5EMZ 5EYA 5GJQ 5GO7 5GO8 5GOB 5GOC 5GOD 5GOG 5GOH 5GOI 5GOJ 5GOK 5H7S 5IBK 5IFR 5JBY 5JG6 5JP3 5JTJ 5JTV 5K9P 5KGF 5KHY 5KYC 5KYD 5KYE 5KYF 5L8H 5L8W 5L9T 5LN1 5LRV 5LRW 5LRX 5M93 5MNJ 5N2W 5N38 5NL5 5NLJ 5NVG 5O44 5O6T 5OHK 5OHL 5OHN 5OHP 5TOF 5TOG 5TUT 5TXK 5UJL 5UJN 5ULF 5ULH 5ULK 5V1Y 5V1Z 5VEY 5VF0 5VNZ 5VO0 5VZM 5VZW 5W46 5WFI 5X3M 5X3N 5X3O 5XBO 5XDP 5XK4 5XK5 5XPK 5YDR 5YIJ 5YIK 5YMY 5YT6 5ZBU 5ZD0 6ASR 6BVA 6BYH 6C16 6CP2 6DGF 6EI1 6FDK 6FGE 6FTX 6FX4 6FYH 6GLC 6GZS 6H4H 6HEI 6HEK 6IF1 6ISU 6JB6 6JB7 6JMA 6K4I 6K9P 6KOW 6KOX 6LP2 6MSB 6MSD 6MSE 6MSG 6N13 6NJG 6O96 6OAM 6PGV 6PZV 6QF8 6QK9 6QML 6TBM 6UH5 6XAA 7CAP 7JMS
Enriched GO Terms of Interacting Partners?
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