POLR1H and IL15

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		POLR1H	IL15
Description		RNA polymerase I subunit H	interleukin 15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase I Complex	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Cell Surface Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding	Cytokine Activity Cytokine Receptor Binding Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase I Transcription MRNA Cleavage	Positive Regulation Of Cytokine Production NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Aging Positive Regulation Of Cell Population Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Cellular Response To Vitamin D Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein O-linked Glycosylation
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	Interleukin-15 signaling Interleukin-15 signaling
Drugs			Cefazolin
Diseases
GWAS			Insomnia ( 29520036) Malaria ( 31844061) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		18 interacting genes: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP MAPK8IP2 NONO SACS SERPINA3 TNS2 TRIML2 UBE2I ZNF593	7 interacting genes: APP IL15RA IL2RB IL2RG POLR1H STAT5B TRAF3
Entrez ID		30834	3600
HPRD ID		09601	02776
Ensembl ID		ENSG00000066379	ENSG00000164136
Uniprot IDs		Q2L6J2 Q9P1U0	P40933
PDB IDs			2XQB 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?
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