RMC1 and MIB1

		RMC1	MIB1
Description		regulator of MON1-CCZ1	MIB E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Late Endosome Membrane Mon1-Ccz1 Complex	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Autophagy Regulation Of Autophagy	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis
Pathways			Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung function (FVC) ( 30804560)	Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)
Interacting Genes		2 interacting genes: C11orf52 MIB1	19 interacting genes: AZI2 BLM CABLES1 CHST9 DAB2 DAPK1 EPB41L4A GABARAP JAG1 RMC1 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN
Entrez ID		29919	57534
HPRD ID		12693	06660
Ensembl ID		ENSG00000141452	ENSG00000101752
Uniprot IDs		A0A087WZD4 B7Z201 B7Z2Y1 B7Z3Q1 K7ENL9 Q96DM3	Q86YT6
PDB IDs			4TSE 4XI6 4XI7 4XIB
Enriched GO Terms of Interacting Partners?
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