GTF2I and USF1

Number of citations of the paper that reports this interaction (PubMedID 1961251)
167

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GTF2I	USF1
Description		general transcription factor IIi	upstream transcription factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of DNA Repair By Transcription From RNA Polymerase II Promoter	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Hypoxia Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Response To UV Late Viral Transcription Cellular Response To Insulin Stimulus Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Carbon Catabolite Regulation Of Transcription Negative Regulation Of Fibrinolysis Lipid Homeostasis
Pathways			Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) SjÃ¶gren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 32771030 28714469)	Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Metabolite levels (lipoprotein measures) ( 27005778) Night sleep phenotypes ( 27126917)
Interacting Genes		46 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 YY1 ZBTB17 ZMYM3	20 interacting genes: APP ESR1 FBXO7 FOS FOSL1 GTF2I HDAC9 HOMEZ LAP3 MAP3K7CL NFYA PLEKHF2 PPARGC1A PRKDC SNW1 TAOK2 TCF3 TCFL5 TRAF2 USF2
Entrez ID		2969	7391
HPRD ID		03399	01880
Ensembl ID		ENSG00000263001	ENSG00000158773
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	A0A0S2Z4U5 P22415
PDB IDs		2D9B 2DN4 2ED2 2EJE	1AN4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?