MYLIP and KANK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MYLIP	KANK4
Description		myosin regulatory light chain interacting protein	KN motif and ankyrin repeat domains 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process	Negative Regulation Of Actin Filament Polymerization
Pathways		VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)	Fuchs's corneal dystrophy ( 28358029) Regular attendance at a gym or sports club ( 29970889)
Interacting Genes		42 interacting genes: ADAMTSL4 AR ARID5A CNPY2 CRK DAPP1 DDIT4L EFHC2 EXOSC5 FAM217B GMCL1 HOOK2 INO80B KANK4 KDM1A LDLR LNX2 LRP8 MIPOL1 MTAP MYL12B NHLRC4 NOXA1 NR1D2 PAX9 RASSF5 SCNM1 SDCBP SRPK2 TCEANC TSC1 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR ZBTB16 ZBTB18 ZBTB42 ZNF417 ZNF438	6 interacting genes: CSK CUL5 HAT1 HOMER3 MYLIP TRAPPC6A
Entrez ID		29116	163782
HPRD ID		17621	14109
Ensembl ID		ENSG00000007944	ENSG00000132854
Uniprot IDs		Q5TIA5 Q8WY64	B1ALP6 Q5T7N3
PDB IDs		2YHN 2YHO 6QLY 6QLZ
Enriched GO Terms of Interacting Partners?
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