GRIK2 and GRIK4

Number of citations of the paper that reports this interaction (PubMedID 12954862)
66

Data Source:
HPRD (in vivo)

		GRIK2	GRIK4
Description		glutamate ionotropic receptor kainate type subunit 2	glutamate ionotropic receptor kainate type subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Excitatory Postsynaptic Potential Detection Of Cold Stimulus Involved In Thermoception	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential
Pathways		Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Activation of Ca-permeable Kainate Receptor
Drugs		Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate	Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Body shape index ( 34021172) Cardiac hypertrophy ( 21348951) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196)	Attention deficit hyperactivity disorder ( 23728934) Cognitive performance ( 20125193) Lateral ventricle volume ( 31530798) Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		18 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25	2 interacting genes: GRIK2 RAB5A
Entrez ID		2898	2900
HPRD ID		00692	02613
Ensembl ID		ENSG00000164418	ENSG00000149403
Uniprot IDs		A8K0H7 Q13002 Q8IY40	A6H8K8 B2RAP6 Q16099
PDB IDs		3QXM 5CMM
Enriched GO Terms of Interacting Partners?
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