TMEM14A and USP18

Number of citations of the paper that reports this interaction (PubMedID 21516116)
114

Data Source:
BioGRID (two hybrid)

		TMEM14A	USP18
Description		transmembrane protein 14A	ubiquitin specific peptidase 18
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane	Nucleus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding ISG15-specific Protease Activity
	Biological Process	Mitochondrial Transport Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Regulation Of Inflammatory Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Response to hepatitis B vaccine ( 29534301)	Systemic lupus erythematosus ( 33272962)
Interacting Genes		35 interacting genes: AQP6 CLN8 CPLX4 CREB3 CREB3L1 CXCR3 ERBB3 ERBB4 ERGIC3 ERMAP IER3IP1 KCNK5 LMNA LRCH1 LXN MMGT1 MTNR1A MTNR1B MUC1 NEMP1 PDZK1IP1 SCN3B SERINC2 SLC10A6 SLC18A1 SLC19A3 SLC7A1 SSMEM1 TMEM14B TMEM179B TMEM31 TMEM51 TMEM80 TMEM86B USP18	6 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 TWIST1 ZDHHC17
Entrez ID		28978	11274
HPRD ID		15522	06136
Ensembl ID		ENSG00000096092	ENSG00000184979
Uniprot IDs		Q9Y6G1	Q9UMW8
PDB IDs		2LOO 2LOP
Enriched GO Terms of Interacting Partners?
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