CCDC22 and CPNE1

Number of citations of the paper that reports this interaction (PubMedID 12522145)
38

Data Source:
HPRD (in vitro)

		CCDC22	CPNE1
Description		coiled-coil domain containing 22	copine 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleoplasm Endosome Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding Cullin Family Protein Binding	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Cellular Copper Ion Homeostasis Golgi To Plasma Membrane Transport Cytoplasmic Sequestering Of NF-kappaB Protein Transport Endocytic Recycling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension
Pathways		Neddylation	Glycerophospholipid biosynthesis Neutrophil degranulation
Drugs			Theophylline
Diseases
GWAS		Vitiligo ( 27723757)	Blood protein levels ( 30072576 29875488 28240269) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: ACTG1 ARSA BLOC1S6 CPNE1 CPNE4 KRT27 OIP5 USHBP1	21 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 TRPC4AP UBE2M UBE2O WTAP
Entrez ID		28952	8904
HPRD ID		06594	05014
Ensembl ID		ENSG00000101997	ENSG00000214078
Uniprot IDs		A0A024QZ03 O60826	B0QZ18 Q99829
PDB IDs
Enriched GO Terms of Interacting Partners?
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