GRIA4 and ABHD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GRIA4	ABHD5
Description		glutamate ionotropic receptor AMPA type subunit 4	abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Extracellular Vesicle	Nucleoplasm Mitochondrion Lipid Droplet Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Ionotropic Glutamate Receptor Activity AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Lipase Activity Protein Binding Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway	Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules	Triglyceride catabolism
Drugs		Glutamic acid Butabarbital Ethanol Talampanel CX-717 Fluciclovine (18F)
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Glioma ( 34319593) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Body shape index ( 34021172) General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12
Entrez ID		2893	51099
HPRD ID		00694	11986
Ensembl ID		ENSG00000152578	ENSG00000011198
Uniprot IDs		P48058 Q1WWK6	A0A0S2Z5D6 Q8WTS1
PDB IDs
Enriched GO Terms of Interacting Partners?
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