GRB7 and KCTD6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		GRB7	KCTD6
Description		growth factor receptor bound protein 7	potassium channel tetramerization domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Cytosol M Band
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Negative Regulation Of Insulin Receptor Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Growth Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization
Pathways		GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling RND1 GTPase cycle	RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474 28461288) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908 20228799)	Hepcidin/transferrin saturation ratio ( 27846281) Refractive error ( 32231278) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)
Interacting Genes		55 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 PTPRC RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1	28 interacting genes: ACTN1 ACTN3 ANK1 BAG4 C8orf33 CDC23 CTNND1 CUL3 EHHADH ERBB2 FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 MOS NTAQ1 PICK1 PPIG PRPF31 PSMA1 REL SDCBP TBC1D2 TCEANC TEPSIN ZCCHC10
Entrez ID		2886	200845
HPRD ID		03311	13769
Ensembl ID		ENSG00000141738	ENSG00000168301
Uniprot IDs		A0A0S2Z4F6 Q14451	Q8NC69
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q
Enriched GO Terms of Interacting Partners?
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