MKNK2 and EIF4G1

Number of citations of the paper that reports this interaction (PubMedID 12897141)
40

Data Source:
BioGRID (enzymatic study)

		MKNK2	EIF4G1
Description		MAPK interacting serine/threonine kinase 2	eukaryotic translation initiation factor 4 gamma 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body	Nucleus Cytoplasm Cytosol Polysome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Translation Protein Phosphorylation Cell Surface Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hemopoiesis Intracellular Signal Transduction Protein Autophosphorylation Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Death Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Differentiation Regulation Of Gene Silencing By MiRNA Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neuron Death Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly Positive Regulation Of MRNA Cap Binding Positive Regulation Of MiRNA Mediated Inhibition Of Translation Regulation Of Polysome Binding
Pathways			ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Fostamatinib
Diseases
GWAS		Nonsyndromic cleft lip with or without cleft palate ( 28087736)	Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)
Interacting Genes		13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1	41 interacting genes: A1CF ANXA5 AP2M1 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		2872	1981
HPRD ID		05459	06774
Ensembl ID		ENSG00000099875	ENSG00000114867
Uniprot IDs		B3KS07 Q9HBH9	B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65
PDB IDs		2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR	1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 6ZMW
Enriched GO Terms of Interacting Partners?
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