GPR37 and HDGF

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		GPR37	HDGF
Description		G protein-coupled receptor 37	heparin binding growth factor
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Collagen-containing Extracellular Matrix
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Nucleotide Binding Transcription Corepressor Binding Double-stranded DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity RNA Binding Growth Factor Activity Heparin Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Signal Transduction Cellular Response To Interleukin-7
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	XBP1(S) activates chaperone genes
Drugs			Copper
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	Blood protein levels ( 30072576) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Refractive error ( 32231278)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	6 interacting genes: APP GPR37 JUN SMAD4 TRAF7 XBP1
Entrez ID		2861	3068
HPRD ID		03992	02079
Ensembl ID		ENSG00000170775	ENSG00000143321
Uniprot IDs		O15354	A0A384NPW1 A8K8G0 B7Z958 P51858
PDB IDs			1RI0 2NLU
Enriched GO Terms of Interacting Partners?
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