ZNF326 and SPTA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZNF326	SPTA1
Description		zinc finger protein 326	spectrin alpha, erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix Intracellular Membrane-bounded Organelle DBIRD Complex	Cytosol Plasma Membrane Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Cell Junction Axon Cortical Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate Cell Projection
	Molecular Function	RNA Polymerase II Complex Binding DNA Binding RNA Binding Protein Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding
	Biological Process	MRNA Processing RNA Splicing Regulation Of DNA-templated Transcription, Elongation Regulation Of RNA Splicing	Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Plasma Membrane Organization Actin Filament Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping
Pathways			NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Brain structure (hippocampal volume) ( 20197096) Major depressive disorder ( 27479909) Obsessive-compulsive symptoms ( 26859814) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)	Glycated hemoglobin levels ( 34059833 20858683 28898252) Hemoglobin A1c levels ( 29844224) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) Platelet distribution width ( 32888494) QRS duration ( 27577874) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: GEMIN4 GYS1 KHDRBS3 KPNA5 NCOA5 PTEN SLC26A4-AS1 SPTA1 VMAC	27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 ODF3B PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326
Entrez ID		284695	6708
HPRD ID		15774	01685
Ensembl ID		ENSG00000162664	ENSG00000163554
Uniprot IDs		A0A0A0MRN4 Q5BKZ1	P02549
PDB IDs			1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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