GNAI1 and S1PR2

Number of citations of the paper that reports this interaction (PubMedID 10488065)
92

Data Source:
HPRD (in vitro)

		GNAI1	S1PR2
Description		G protein subunit alpha i1	sphingosine-1-phosphate receptor 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding G Protein-coupled Peptide Receptor Activity Sphingosine-1-phosphate Receptor Activity
	Biological Process	Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex	Sphingosine-1-phosphate Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Metabolic Process Actin Cytoskeleton Reorganization Filopodium Assembly Negative Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs		Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Nicotine dependence ( 33144568) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)	Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		62 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CMKLR2 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GNG2 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	4 interacting genes: GNA13 GNAI1 GNAQ KEAP1
Entrez ID		2770	9294
HPRD ID		00756	05488
Ensembl ID		ENSG00000127955	ENSG00000267534
Uniprot IDs		P63096	A0A024R7B2 O95136
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM 7JVR 7L0P 7L0Q 7L0R 7L0S	1ZTI
Enriched GO Terms of Interacting Partners?
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