GNA15 and RGS2

Number of citations of the paper that reports this interaction (PubMedID 12885252)
21

Data Source:
HPRD (in vivo, in vitro)

		GNA15	RGS2
Description		G protein subunit alpha 15	regulator of G protein signaling 2
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Action Potential Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway	Response To Amphetamine Cell Cycle G Protein-coupled Receptor Signaling Pathway Spermatogenesis Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Ovulation Negative Regulation Of MAP Kinase Activity Negative Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	G alpha (q) signalling events
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634 32296059) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	62 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A SUN2 TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		2769	5997
HPRD ID		00760	02917
Ensembl ID		ENSG00000060558	ENSG00000116741
Uniprot IDs		P30679	A0A024R939 P41220
PDB IDs			2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?
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