APOBEC3C and TRAF3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		APOBEC3C	TRAF3
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 3C	TNF receptor associated factor 3
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Signaling Receptor Complex
	Molecular Function	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Deoxycytidine Deaminase Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Cytidine Deamination Negative Regulation Of Transposition Cytidine To Uridine Editing Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination DNA Demethylation	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Defense Response To Virus Protein K63-linked Ubiquitination
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Eczema ( 31361310) Gallstone disease ( 30692554) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) HDL cholesterol levels ( 32203549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Major depressive disorder (MTAG) ( 33479212) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Red blood cell count ( 32888494) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 33536424 28714469) Type 2 diabetes ( 32499647)
Interacting Genes		19 interacting genes: CHTOP FBXO7 HHEX HNRNPK PRR3 RBMX RBMY1A1 RBMY1F RBMY1J SHBG SRPK2 STK4 SUN2 TRAF3 TRIB3 ZNF250 ZNF408 ZNF48 ZNF581	85 interacting genes: ABCC1 ALPL APOBEC3C ASCC1 AZI2 BEX3 BIRC3 BIVM C10orf62 CASP3 CCDC13 CCDC184 CD27 CD40 CDC37 CELF2 DAXX EDA2R EDAR EWSR1 FAS GMEB2 GRIN1 GRIN2D HEMGN HNRNPC HSPB11 IL15 IP6K3 IRF1 LNX1 LTBR MAP2K1 MAP3K14 MAP3K7 NTAQ1 NUP62 OTUD5 PDLIM7 PDZD4 PIAS2 POM121 PSMB8 PTPN6 RAD23A RIPK1 RIPPLY1 RNF216 RNF4 RRAS2 SAR1A SHANK3 SNAP29 SRC STK38 TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM24 TRIM37 UBE2I USP7 ZBP1 ZBTB49 ZMYND11 ZSCAN4
Entrez ID		27350	7187
HPRD ID		09671	03539
Ensembl ID		ENSG00000244509	ENSG00000131323
Uniprot IDs		Q9NRW3	A6NHG8 Q13114
PDB IDs		3VM8 3VOW	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?
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