PRPF19 and VPS35

Number of citations of the paper that reports this interaction (PubMedID 33305682)
2

Data Source:
BioGRID (unspecified method)

		PRPF19	VPS35
Description		pre-mRNA processing factor 19	VPS35 retromer complex component
Image
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Cytoplasm Lipid Droplet Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Retromer Complex Retromer, Cargo-selective Complex Extracellular Exosome Tubular Endosome Mitochondrion-derived Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding D1 Dopamine Receptor Binding
	Biological Process	DNA Damage Checkpoint Signaling Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Nonhomologous End Joining Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Cellular Protein Localization Positive Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination	Intracellular Protein Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Regulation Of Cellular Protein Metabolic Process Endocytic Recycling Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Mitochondrial Fission Mitochondrion To Lysosome Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Negative Regulation Of Neuron Death Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Presynapse Assembly Regulation Of Terminal Button Organization
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Interacting Genes		16 interacting genes: DDX42 DNTT EGLN3 ESR1 EXOC7 GSTK1 HSPB1 OGT POLR2A PRPF8 PSMB4 PTEN RPA3 U2AF1 UBE2D3 VPS35	15 interacting genes: APP DRD1 GNL1 LINC01554 MTNR1B PRPF19 SLC11A2 SNX1 SNX3 VEGFA VPS26A VPS26B VPS29 YBX1 ZNF512B
Entrez ID		27339	55737
HPRD ID		12214	06085
Ensembl ID		ENSG00000110107	ENSG00000069329
Uniprot IDs		Q9UMS4	Q96QK1
PDB IDs		4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P	2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI 7BLN 7BLO
Enriched GO Terms of Interacting Partners?
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