SDCBP2 and CTH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SDCBP2	CTH
Description		syndecan binding protein 2	cystathionine gamma-lyase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Carbon-sulfur Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity
	Biological Process	Nervous System Development Cell Population Proliferation Intracellular Signal Transduction Intracellular Transport	Cysteine Metabolic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Sulfhydration Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Brain volume in infants (grey matter) ( 28763065) Declining hemoglobin trajectory in blood donors ( 33491795) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Seasonality and depression ( 30217971)
Interacting Genes		65 interacting genes: ADAP1 AKAP17A AP1M1 ARF4 BEND7 C1orf35 CHCHD1 CRCT1 CRY2 CT45A1 CT45A10 CT45A3 CT45A5 CTH DMC1 DPPA2 EIF1AD FAM133A FAM13C FAM9B FBXO28 GABRA3 HSBP1 LGALS14 LGALS2 LYAR MED4 NFASC NFU1 NKAPD1 NOP56 NPM2 NRXN1 NUF2 PAFAH1B3 PHC1 PRM2 PRPF38A PRPF40A PRR13 PTMS RNF111 RNPS1 RPL22 RPL22L1 RPL41 SDCBP SEC23A SREK1IP1 SYT17 TCP11L1 TDO2 THAP6 TIFA TM4SF1 TNNT1 TNP1 TRAF1 VAX1 VPS25 YTHDC1 ZCCHC10 ZCCHC17 ZNF581 ZRSR2	5 interacting genes: GUCD1 NTAQ1 PTGFR RECK SDCBP2
Entrez ID		27111	1491
HPRD ID		18032	09633
Ensembl ID		ENSG00000125775	ENSG00000116761
Uniprot IDs		Q9H190	P32929
PDB IDs			2NMP 3COG 3ELP 5EIG 5TSU 5TT2 6NBA 6OVG
Enriched GO Terms of Interacting Partners?
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