ANKRD1 and CASQ2

Number of citations of the paper that reports this interaction (PubMedID 15698842)
13

Data Source:
HPRD (in vitro)

		ANKRD1	CASQ2
Description		ankyrin repeat domain 1	calsequestrin 2
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol I Band	Cytoplasm Junctional Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	P53 Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Protein Kinase C Signaling Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Biosynthetic Process	Regulation Of Heart Rate Detection Of Calcium Ion Striated Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Potassium Ion Transport Sequestering Of Calcium Ion Protein Polymerization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cardiac Muscle Contraction Regulation Of Membrane Repolarization Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		PPARA activates gene expression	Stimuli-sensing channels Ion homeostasis
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Refractive error ( 32231278)	Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricle wall thickness ( 33495596) Left ventricular global radial strain ( 33495596) Pulse pressure ( 30578418) QRS duration ( 27577874 30012220 27659466)
Interacting Genes		23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446	5 interacting genes: ANKRD1 CSNK2A1 CSNK2A2 FBXO7 TRDN
Entrez ID		27063	845
HPRD ID		10647	00256
Ensembl ID		ENSG00000148677	ENSG00000118729
Uniprot IDs		A0A384NYH5 Q15327	O14958
PDB IDs			2VAF 6OWV 6OWW
Enriched GO Terms of Interacting Partners?
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