GDI2 and RAB4A

Number of citations of the paper that reports this interaction (PubMedID 10512627)
20

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		GDI2	RAB4A
Description		GDP dissociation inhibitor 2	RAB4A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Focal Adhesion Membrane Vesicle Secretory Granule Lumen Azurophil Granule Lumen Synapse Extracellular Exosome	Endosome Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	RNA Binding Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	ATPase Activator Activity GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Protein Transport Vesicle-mediated Transport Regulation Of Catalytic Activity	Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Osteosarcoma ( 23727862)	Aging ( 22773346) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)
Interacting Genes		11 interacting genes: GATA3 GLRA2 HSPB1 LINC01554 OGT RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A	33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 FAM71C GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830
Entrez ID		2665	5867
HPRD ID		02863	01541
Ensembl ID		ENSG00000057608	ENSG00000168118
Uniprot IDs		P50395 Q6IAT1	A0A024R3U9 A0A087WYT5 P20338
PDB IDs			1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?
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