ELP4 and ELP3

Number of citations of the paper that reports this interaction (PubMedID 22939629)
326

Data Source:
BioGRID (biochemical)

		ELP4	ELP3
Description		elongator acetyltransferase complex subunit 4	elongator acetyltransferase complex subunit 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Nucleus Nucleolus Cytoplasm Cytosol Elongator Holoenzyme Complex
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding Phosphorylase Kinase Regulator Activity	TRNA Binding Protein Binding N-acetyltransferase Activity Phosphorylase Kinase Regulator Activity Acetyltransferase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding TRNA Uridine(34) Acetyltransferase Activity
	Biological Process	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Regulation Of Catalytic Activity	Neuron Migration TRNA Wobble Uridine Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Positive Regulation Of Cell Migration Regulation Of Catalytic Activity
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Glaucoma ( 25027321) Mental health study participation (completed survey) ( 31263887) Optic disc area ( 25631615) Optic disc size ( 31809533) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Malaria ( 31844061) Systemic lupus erythematosus ( 28714469)
Interacting Genes		6 interacting genes: ELP3 FDFT1 HINFP NAGK PAMR1 PPP1CC	7 interacting genes: CTDP1 ELP1 ELP4 H3C14 H4C1 SMAD1 SMURF1
Entrez ID		26610	55140
HPRD ID		07377	10936
Ensembl ID		ENSG00000109911	ENSG00000134014
Uniprot IDs		G5E9D4 Q96EB1	B4DKA4 B4DXV1 Q9H9T3
PDB IDs
Enriched GO Terms of Interacting Partners?
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