TINF2 and HNMT

Number of citations of the paper that reports this interaction (PubMedID 21044950)
51

Data Source:
BioGRID (two hybrid)

		TINF2	HNMT
Description		TERF1 interacting nuclear factor 2	histamine N-methyltransferase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Nucleoplasm Cytoplasm Centrosome Cytosol Neuron Projection Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Histamine N-methyltransferase Activity
	Biological Process	Negative Regulation Of Protein ADP-ribosylation Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Histamine Metabolic Process Histamine Catabolic Process Response To Tumor Cell Histidine Catabolic Process Hyperosmotic Response Brain Development Respiratory Gaseous Exchange By Respiratory System Response To Amine Methylation Response To Immobilization Stress Response To Cocaine Response To Glucocorticoid Response To Interleukin-1
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Metabolism of ingested SeMet, Sec, MeSec into H2Se Histidine catabolism
Drugs			Amodiaquine S-adenosyl-L-homocysteine Metoprine SKF-91488 Harmaline
Diseases
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)	Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		89 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	5 interacting genes: CAMK2D CLK1 POT1 TERF1 TINF2
Entrez ID		26277	3176
HPRD ID		16056	05575
Ensembl ID		ENSG00000092330	ENSG00000150540
Uniprot IDs		Q9BSI4	B4DWC1 P50135
PDB IDs		3BQO 3BU8 5XYF	1ICZ 1JQD 1JQE 2AOT 2AOU 2AOV 2AOW 2AOX
Enriched GO Terms of Interacting Partners?
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