FBXO4 and ELF4

Number of citations of the paper that reports this interaction (PubMedID 16581786)
18

Data Source:
HPRD (in vivo)

		FBXO4	ELF4
Description		F-box protein 4	E74 like ETS transcription factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Chromatin Nucleus Nucleoplasm Nuclear Body PML Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Aging Posttranscriptional Regulation Of Gene Expression Protein Ubiquitination Cellular Homeostasis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Telomere Maintenance Via Telomerase Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Fibroblast Proliferation Cellular Response To Ionizing Radiation Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Polyubiquitination Regulation Of DNA Damage Checkpoint	Natural Killer Cell Proliferation NK T Cell Proliferation Regulation Of Transcription By RNA Polymerase II Cell Differentiation Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756)
Interacting Genes		8 interacting genes: CCND1 CDC34 ELF4 FXR1 SKP1 TERF1 TNNI3K UBE2D2	12 interacting genes: CASP4 CFC1 FBXO4 FBXO7 NFE2L2 NPM1 PML PSMD8 RUNX1 SET SKP2 UBB
Entrez ID		26272	2000
HPRD ID		09949	06499
Ensembl ID		ENSG00000151876	ENSG00000102034
Uniprot IDs		B3KNA0 D6RAJ6 Q9UKT5	Q99607
PDB IDs		3L2O 3L82
Enriched GO Terms of Interacting Partners?
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