FBXL4 and GP1BA

		FBXL4	GP1BA
Description		F-box and leucine rich repeat protein 4	glycoprotein Ib platelet subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mitochondrial Intermembrane Space Cytosol Nuclear Speck SCF Ubiquitin Ligase Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Anchored Component Of External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Thrombin-activated Receptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Thrombin-activated Receptor Signaling Pathway Platelet Aggregation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation
Drugs			Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases
GWAS		Chronotype ( 30696823) Depression ( 29700475) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889)	Blood protein levels ( 30072576 29875488) Keratoconus ( 33649486) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)
Interacting Genes		4 interacting genes: GP1BA MAP3K7 RXRG SKP1	18 interacting genes: CTSG DDIT3 F11 F12 F2 FBXL4 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		26235	2811
HPRD ID		05738	01976
Ensembl ID		ENSG00000112234	ENSG00000185245
Uniprot IDs		Q9UKA2	L7UYB8 P07359
PDB IDs			1GWB 1K13 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6
Enriched GO Terms of Interacting Partners?
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