GMEB2 and CDC7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GMEB2	CDC7
Description		glucocorticoid modulatory element binding protein 2	cell division cycle 7
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division
Pathways			Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 23535732) Refractive error ( 32231278) Reticulocyte count ( 32888494)	Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Plateletcrit ( 32888494) PR interval ( 32439900) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		21 interacting genes: ATXN1 ATXN1L CBFA2T3 CDC7 CEP19 CREBBP FHL2 GMEB1 LMO2 LMO3 MAP1LC3C MOB1A MXRA8 PIN1 POGZ POU6F2 PVR TRAF3 TTF2 UBE2I ZMYND19	53 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN CSDE1 DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B
Entrez ID		26205	8317
HPRD ID		16245	10345
Ensembl ID		ENSG00000101216	ENSG00000097046
Uniprot IDs		B4DQS0 Q9UKD1	A0A384MTU6 B2R6V2 O00311
PDB IDs			4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?
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