LDLRAP1 and C6orf58

Number of citations of the paper that reports this interaction (PubMedID 27107012)
40

Data Source:
BioGRID (two hybrid)

		LDLRAP1	C6orf58
Description		low density lipoprotein receptor adaptor protein 1	chromosome 6 open reading frame 58
Image			No pdb structure
GO Annotations	Cellular Component	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome	Extracellular Space Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding
	Biological Process	Receptor-mediated Endocytosis Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)	Asthma ( 31959851) Hepcidin/ferritin ratio ( 27846281) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172)
Interacting Genes		18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 STN1 TFAP2A	1 interacting genes: LDLRAP1
Entrez ID		26119	352999
HPRD ID		05765
Ensembl ID		ENSG00000157978	ENSG00000184530
Uniprot IDs		B3KR97 Q5SW96	Q6P5S2
PDB IDs		2G30
Enriched GO Terms of Interacting Partners?
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