ZZZ3 and TRIM22

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		ZZZ3	TRIM22
Description		zinc finger ZZ-type containing 3	tripartite motif containing 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Histone H4 Acetylation	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus
Pathways		HATs acetylate histones	Interferon gamma signaling
Drugs
Diseases
GWAS		Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Height ( 31562340) Hip circumference ( 25673412) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Obesity ( 23563607) Platelet count ( 32888494) Type 2 diabetes (age of onset) ( 28060188) Waist-to-hip ratio adjusted for BMI ( 34021172)	Coronary artery disease ( 29212778) Malaria ( 31844061)
Interacting Genes		21 interacting genes: BLZF1 CARD9 DNAJB11 EFHC2 EPS8 FAM124A GATA1 GOLGA2 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 PICK1 PPP1R13B TRAF2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513	12 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RERE TAF7 UBE2D1 USP7 ZZZ3
Entrez ID		26009	10346
HPRD ID		15907	05951
Ensembl ID		ENSG00000036549	ENSG00000132274
Uniprot IDs		Q8IYH5	B4DQS5 Q8IYM9
PDB IDs		2FC7 2YUM 6E83 6E86
Enriched GO Terms of Interacting Partners?
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