NGEF and C7orf25

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		NGEF	C7orf25
Description		neuronal guanine nucleotide exchange factor	chromosome 7 open reading frame 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Growth Cone
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding
	Biological Process	Nervous System Development Cell Differentiation Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity
Pathways		NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 30598549 28869591) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)	Asthma ( 29273806) Ceramide levels (C24:0) ( 32489964)
Interacting Genes		18 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK MRPL44 NUDT21 RHOA SEPTIN2 SH2D1A SMO TAF1D TRIM55 TRIM63 TTK USP25 YIPF3	20 interacting genes: BRD4 CEP70 CRYM DACT1 EZH2 FRA10AC1 FYN FZR1 GTPBP1 HAP1 HEXD MTOR MX1 NGEF PTN RASSF1 RPL36AL SF3B2 TARS1 UBE2D1
Entrez ID		25791	79020
HPRD ID		10442	09861
Ensembl ID		ENSG00000066248	ENSG00000136197
Uniprot IDs		B4DDI2 Q8N5V2	Q9BPX7
PDB IDs
Enriched GO Terms of Interacting Partners?
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