SHPRH and FDFT1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHPRH	FDFT1
Description		SNF2 histone linker PHD RING helicase	farnesyl-diphosphate farnesyltransferase 1
Image
GO Annotations	Cellular Component	Nucleosome Nucleoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity ATP-dependent Chromatin Remodeler Activity	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Protein Ubiquitination	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Farnesyl Diphosphate Metabolic Process
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs			TAK-475
Diseases
GWAS			Blood protein levels ( 28240269) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 H3C1 H4C1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG	26 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 ELP4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35C2 TLCD4 TMEM43 TMX2
Entrez ID		257218	2222
HPRD ID		10476	01694
Ensembl ID		ENSG00000146414	ENSG00000079459
Uniprot IDs		B3KX98 Q149N8	A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1
PDB IDs		2M85 4QN1	1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5
Enriched GO Terms of Interacting Partners?
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