GABRA1 and MAT2B

		GABRA1	MAT2B
Description		gamma-aminobutyric acid type A receptor subunit alpha1	methionine adenosyltransferase 2B
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Dendrite Membrane Chloride Channel Complex Neuron Projection Synapse Postsynapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane GABA Receptor Complex GABA-A Receptor Complex	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome
	Molecular Function	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity Diazepam Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity
	Biological Process	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Regulation Of Catalytic Activity
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	Methylation Ub-specific processing proteases
Drugs		Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Topiramate Etomidate Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Carisoprodol Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Picrotoxin Methohexital Chlordiazepoxide Chlordiazepoxide Amoxapine Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Acamprosate Midazolam Midazolam Flurazepam Flurazepam Isoflurane Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Progabide Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zaleplon Methoxyflurane Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Methyprylon Thiamylal Halothane Halothane Phenobarbital Desflurane Zopiclone Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Sevoflurane Dihydroquinidine barbiturate Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Ginkgo biloba Glutethimide Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Clomethiazole Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol Benzodiazepine Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2â€²-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Gait speed in old age ( 28077804)	Age at first sexual intercourse ( 34211149) Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		6 interacting genes: DRD4 MAT2B PPP3CA PRKCD PRKCG UBQLN1	16 interacting genes: APP CNIH4 FBXO25 GABRA1 HRH1 KPNA3 KPNA4 MAT2A MSX2 PLA2G6 RABEP1 STC1 TEPSIN TMED9 TRIM27 YTHDF3
Entrez ID		2554	27430
HPRD ID		00662	05701
Ensembl ID		ENSG00000022355	ENSG00000038274
Uniprot IDs		A8K177 P14867	A0A140VJP2 Q9NZL9
PDB IDs		6CDU 6D1S 6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40	2YDX 2YDY 4KTT 4KTV 4NDN
Enriched GO Terms of Interacting Partners?
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