FYN and BCL3

  • Number of citations of the paper that reports this interaction (PubMedID 9576921)
  • 87
  • Data Source:
  • HPRD (in vivo)

FYN

BCL3

Description FYN proto-oncogene, Src family tyrosine kinase BCL3 transcription coactivator
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease ( 30636644 24755620)
  • Alzheimer's disease (late onset) ( 23565137)
  • Alzheimer's disease (onset between ages 58 and 79) ( 30979435)
  • Alzheimer's disease or family history of Alzheimer's disease ( 30617256)
  • Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717)
  • Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
  • Apolipoprotein A1 levels ( 32203549)
  • Apolipoprotein B levels ( 32203549)
  • Asthma ( 32296059)
  • Body mass index ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x age interaction ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Eosinophil counts ( 32888494)
  • Eosinophil percentage of white cells ( 32888494 27863252)
  • HDL cholesterol levels ( 32203549)
  • HDL cholesterol levels in current drinkers ( 30698716)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • LDL cholesterol levels ( 30698716)
  • LDL cholesterol levels in current drinkers ( 30698716)
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes 200 interacting genes: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BAG4 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DLGAP4 DOK1 DOK3 DOK4 DTX3 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 ERRFI1 EVL FAM90A1 FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB1 GAB3 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B HDAC2 HNRNPK HRAS HSP90AA1 HTR6 IGHA1 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCK LCP2 MAG MAP2 MAPT MCAM MED28 MEOX2 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NOS1AP NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PRMT8 PRRG4 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RACK1 RAF1 RPL10 RPS6KA3 RPS6KB2 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TAMALIN TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRIM55 TRIM63 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70 36 interacting genes: AKT1 ANKRD28 BARD1 CHUK COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK1 MAPK3 MAPRE1 N4BP2 NCOA1 NFKB1 NFKB2 PIR RAB9A RELA RUVBL2 RXRA SHC1 TBP TRAF6
Entrez ID 2534 602
HPRD ID 00655 00179
Ensembl ID ENSG00000010810 ENSG00000069399
Uniprot IDs P06241 B7Z3N9 P20749
PDB IDs 1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 2MQI 2MRJ 2MRK 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX 5ZAU 6EDF 6IPY 6IPZ 1K1A 1K1B
Enriched GO Terms of Interacting Partners?
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