PRKD3 and KPNB1

Number of citations of the paper that reports this interaction (PubMedID 16380377)
13

Data Source:
HPRD (in vivo)

		PRKD3	KPNB1
Description		protein kinase D3	karyopherin subunit beta 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane	Extracellular Region Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Membrane Specific Granule Lumen Extracellular Exosome Endoplasmic Reticulum Tubular Network Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Small GTPase Binding Hsp90 Protein Binding Nuclear Import Signal Receptor Activity Importin-alpha Family Protein Binding
	Biological Process	Protein Phosphorylation Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Sphingolipid Biosynthetic Process Protein Kinase D Signaling	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Astral Microtubule Organization Ran Protein Signal Transduction Establishment Of Mitotic Spindle Localization Establishment Of Protein Localization Mitotic Spindle Assembly
Pathways		Sphingolipid de novo biosynthesis	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production
Drugs
Diseases
GWAS		Alzheimer's disease ( 34099642) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 28165464 24292274) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Pulse pressure ( 27841878) Schizophrenia ( 33169155 23974872) Systolic blood pressure ( 28135244 27841878)	Asthma ( 31619474) Body mass index ( 26426971) Glycine levels ( 30837465) HDL cholesterol ( 30275531) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 22190364) Optic cup area ( 25631615) Simvastatin-induced myopathy ( 31220337) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		13 interacting genes: BCL6 DLAT DYNLL2 GSK3A IKBKG KPNA2 KPNB1 MYH3 NUDT3 POLL SKA2 TAF1 VAMP2	69 interacting genes: AMFR CD99 CHD3 CRBN CSE1L CSNK1A1 CUL4B ELAVL1 EPAS1 EXO1 FGFR1 H1-0 H1-2 IGFBP3 IGFBP5 IPO7 IPO8 ITCH KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LINC01554 LYST MESD MSL1 MTNR1A NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 OGT PIAS4 PLCD1 PRKD3 PTEN PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RBX1 RPL5 RUNX1T1 SELENOS SENP2 SMAD2 SMAD3 SMN1 SMNDC1 SNAI1 SNAPIN SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5
Entrez ID		23683	3837
HPRD ID		06151	04114
Ensembl ID		ENSG00000115825	ENSG00000108424
Uniprot IDs		O94806	B7Z752 Q14974
PDB IDs		2D9Z	1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89
Enriched GO Terms of Interacting Partners?
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