Description |
beta-secretase 1 |
STIP1 homology and U-box containing protein 1 |
Image |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- MMI-175
- CTS-21166
- N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
- N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
- N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
- 4-(4-FLUOROBENZYL)PIPERIDINE
- N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
- 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
- 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
- N~3~-BENZYLPYRIDINE-2,3-DIAMINE
- N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
- N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
- 4-(2-aminoethyl)-2-cyclohexylphenol
- 4-(2-aminoethyl)-2-ethylphenol
- 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
- (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
- 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
- (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
- N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
- N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
- (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
- (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
- N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
- (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
- N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
- N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
- 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
- Verubecestat
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Diseases |
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GWAS |
- Blood protein levels ( 28240269)
- Cardiovascular disease risk factors ( 21779381)
- Diffusing capacity of carbon monoxide ( 30694715)
- Mean platelet volume ( 32888494)
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- Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
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Interacting Genes |
24 interacting genes:
ADRB2
APP
ATP1B1
BRI3
CMPK1
CSNK1D
FBXO2
FURIN
GGA1
GGA2
ITM2C
KHSRP
LRP1
MMP2
NCSTN
PCSK9
PDIA3
PLSCR1
PSAP
PSEN1
RANBP9
SELPLG
STUB1
USP8
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135 interacting genes:
ABL1
ACD
ADRM1
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BCR
BMPR1B
CASP6
CCL28
CDK4
CDKN1A
CFTR
CIP2A
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FXR1
GHR
GPR37
GUCY1A1
GUCY1A2
HIF1A
HSF1
HSP90AA1
HSP90AB1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
INSR
JOSD1
JOSD2
KHDRBS1
LRRK1
LRRK2
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MAST1
MCF2
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
OTUD3
PA2G4
PFN1
PLK1
PMAIP1
POLB
POT1
PPARG
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PRMT5
PSMA3
PSMC2
PSMD1
PSMD2
PSMD4
PTEN
RAF1
RGS17
RHBDF2
RUNX2
RUSC1
S100A2
S100P
SIRT6
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TP53
TP73
TPD52
TRAF6
TXN2
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
VCP
XIAP
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Entrez ID |
23621 |
10273 |
HPRD ID |
07255 |
06232 |
Ensembl ID |
ENSG00000186318
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ENSG00000103266
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Uniprot IDs |
A0A024R3D5
A0A024R3D7
A0A024R3E8
A0A024R3F9
B7Z3K2
B7Z3Z4
P56817
Q5W9H2
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Q9UNE7
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PDB IDs |
1FKN
1M4H
1PY1
1SGZ
1TQF
1UJJ
1UJK
1W50
1W51
1XN2
1XN3
1XS7
1YM2
1YM4
2B8L
2B8V
2F3E
2F3F
2FDP
2G94
2HIZ
2HM1
2IQG
2IRZ
2IS0
2NTR
2OAH
2OF0
2OHK
2OHL
2OHM
2OHN
2OHP
2OHQ
2OHR
2OHS
2OHT
2OHU
2P4J
2P83
2P8H
2PH6
2PH8
2Q11
2Q15
2QK5
2QMD
2QMF
2QMG
2QP8
2QU2
2QU3
2QZK
2QZL
2VA5
2VA6
2VA7
2VIE
2VIJ
2VIY
2VIZ
2VJ6
2VJ7
2VJ9
2VKM
2VNM
2VNN
2WEZ
2WF0
2WF1
2WF2
2WF3
2WF4
2WJO
2XFI
2XFJ
2XFK
2ZDZ
2ZE1
2ZHR
2ZHS
2ZHT
2ZHU
2ZHV
2ZJH
2ZJI
2ZJJ
2ZJK
2ZJL
2ZJM
2ZJN
3BRA
3BUF
3BUG
3BUH
3CIB
3CIC
3CID
3CKP
3CKR
3DM6
3DUY
3DV1
3DV5
3EXO
3FKT
3H0B
3HVG
3HW1
3I25
3IGB
3IN3
3IN4
3IND
3INE
3INF
3INH
3IVH
3IVI
3IXJ
3IXK
3K5C
3K5D
3K5F
3K5G
3KMX
3KMY
3KN0
3KYR
3L38
3L3A
3L58
3L59
3L5B
3L5C
3L5D
3L5E
3L5F
3LHG
3LNK
3LPI
3LPJ
3LPK
3MSJ
3MSK
3MSL
3N4L
3NSH
3OHF
3OHH
3OOZ
3PI5
3QBH
3QI1
3R1G
3R2F
3RSV
3RSX
3RTH
3RTM
3RTN
3RU1
3RVI
3S2O
3S7L
3S7M
3SKF
3SKG
3TPJ
3TPL
3TPP
3TPR
3U6A
3UDH
3UDJ
3UDK
3UDM
3UDN
3UDP
3UDQ
3UDR
3UDY
3UFL
3UQP
3UQR
3UQU
3UQW
3UQX
3VEU
3VF3
3VG1
3VV6
3VV7
3VV8
3WB4
3WB5
3ZMG
3ZOV
4ACU
4ACX
4AZY
4B00
4B05
4B0Q
4B1C
4B1D
4B1E
4B70
4B72
4B77
4B78
4BEK
4BFD
4D83
4D85
4D88
4D89
4D8C
4DH6
4DI2
4DJU
4DJV
4DJW
4DJX
4DJY
4DPF
4DPI
4DUS
4DV9
4DVF
4EWO
4EXG
4FCO
4FGX
4FM7
4FM8
4FRI
4FRJ
4FRK
4FRS
4FS4
4FSE
4FSL
4GID
4GMI
4H1E
4H3F
4H3G
4H3I
4H3J
4HA5
4HZT
4I0D
4I0E
4I0F
4I0G
4I0H
4I0I
4I0J
4I0Z
4I10
4I11
4I12
4I1C
4IVS
4IVT
4J0P
4J0T
4J0V
4J0Y
4J0Z
4J17
4J1C
4J1E
4J1F
4J1H
4J1I
4J1K
4JOO
4JP9
4JPC
4JPE
4K8S
4K9H
4KE0
4KE1
4L7G
4L7H
4L7J
4LC7
4LXA
4LXK
4LXM
4N00
4PZW
4PZX
4R5N
4R8Y
4R91
4R92
4R93
4R95
4RCD
4RCE
4RCF
4RRN
4RRO
4RRS
4TRW
4TRY
4TRZ
4WTU
4WY1
4WY6
4X2L
4X7I
4XKX
4XXS
4YBI
4ZPE
4ZPF
4ZPG
4ZSM
4ZSP
4ZSQ
4ZSR
5CLM
5DQC
5ENK
5ENM
5EZX
5EZZ
5F00
5F01
5HD0
5HDU
5HDV
5HDX
5HDZ
5HE4
5HE5
5HE7
5HTZ
5HU0
5HU1
5I3V
5I3W
5I3X
5I3Y
5IE1
5KQF
5KR8
5MBW
5MCO
5MCQ
5MXD
5QCO
5QCP
5QCQ
5QCR
5QCS
5QCT
5QCU
5QCV
5QCW
5QCX
5QCY
5QCZ
5QD0
5QD1
5QD2
5QD3
5QD4
5QD5
5QD6
5QD7
5QD8
5QD9
5QDA
5QDB
5QDC
5QDD
5T1U
5T1W
5TOL
5UYU
5V0N
5YGX
5YGY
6BFD
6BFE
6BFW
6BFX
6C2I
6DHC
6DMI
6E3Z
6EJ2
6EJ3
6EQM
6FGY
6JSE
6JSF
6JSG
6JSN
6JT3
6JT4
6NV7
6NV9
6NW3
6OD6
6PZ4
6UVP
6UVV
6UVY
6UWP
6UWV
6WNY
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4KBQ
6EFK
6NSV
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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