ORC3 and DBF4

Number of citations of the paper that reports this interaction (PubMedID 12441400)
46

Data Source:
HPRD (in vivo, two hybrid)

		ORC3	DBF4
Description		origin recognition complex subunit 3	DBF4 zinc finger
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Nuclear Body DNA Replication Preinitiation Complex	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex
	Molecular Function	DNA Replication Origin Binding Protein Binding	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	DNA Replication DNA Replication Initiation Regulation Of DNA Replication Neural Precursor Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Metabolite levels ( 23823483)
Interacting Genes		21 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 DBF4 FBXO7 H3-4 H4-16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2	18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		23595	10926
HPRD ID		05398	10371
Ensembl ID		ENSG00000135336	ENSG00000006634
Uniprot IDs		Q9UBD5	B4DXK0 B7Z8C6 Q9UBU7
PDB IDs		5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS	4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?
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