PIK3R5 and SNX9

Number of citations of the paper that reports this interaction (PubMedID 17242350)
37

Data Source:
BioGRID (pull down)

		PIK3R5	SNX9
Description		phosphoinositide-3-kinase regulatory subunit 5	sorting nexin 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IB Membrane Centriolar Satellite	Ruffle Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Cuticular Plate Extracellular Exosome
	Molecular Function	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Positive Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase B Signaling	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Protein-containing Complex Assembly Plasma Membrane Tubulation
Pathways		GPVI-mediated activation cascade Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Atypical femoral fracture in phosphonate treatment ( 31006051) Autoimmune thyroid disease ( 32581359) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494)	Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 32888494 27863252)
Interacting Genes		4 interacting genes: APP PIK3CG SDHB SNX9	23 interacting genes: ADAM15 ADAM9 AP1G1 CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MPHOSPH6 PAK2 PALS2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL
Entrez ID		23533	51429
HPRD ID		11433	12072
Ensembl ID		ENSG00000141506	ENSG00000130340
Uniprot IDs		J3KSW1 L7RT34 Q8WYR1	Q9Y5X1
PDB IDs			2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE
Enriched GO Terms of Interacting Partners?
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