ABCA5 and CYP2E1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ABCA5	CYP2E1
Description		ATP binding cassette subfamily A member 5	cytochrome P450 family 2 subfamily E member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Lipid Transporter Activity ATP Binding ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Hsp90 Protein Binding Aromatase Activity
	Biological Process	Lipid Transport Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Cholesterol Efflux High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Transmembrane Transport Positive Regulation Of Reverse Cholesterol Transport	Lipid Hydroxylation Organic Acid Metabolic Process Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Halogenated Hydrocarbon Metabolic Process Long-chain Fatty Acid Biosynthetic Process Response To Ethanol Heterocycle Metabolic Process
Pathways		ABC transporters in lipid homeostasis	Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs
Drugs			Diacerein
Diseases
GWAS		Blood protein levels ( 29875488) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Iron status biomarkers (iron levels) ( 33536631) Metabolite levels ( 23823483) Normal facial asymmetry (deformation magnitude) ( 30631343)	Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		2 interacting genes: CYP2E1 NR4A1	15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1
Entrez ID		23461	1571
HPRD ID		09789	11813
Ensembl ID		ENSG00000154265	ENSG00000130649
Uniprot IDs		Q8WWZ7	P05181
PDB IDs			3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?
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