FNTB and PTP4A3

Number of citations of the paper that reports this interaction (PubMedID 10747914)
46

Data Source:
HPRD (in vitro)

		FNTB	PTP4A3
Description		farnesyltransferase, CAAX box, beta	protein tyrosine phosphatase 4A3
Image
GO Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex	Nucleus Cytoplasm Early Endosome Plasma Membrane
	Molecular Function	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding	Protein Tyrosine Phosphatase Activity Prenylated Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Protein Prenylation Protein Farnesylation	Regulation Of Transcription, DNA-templated Notch Signaling Pathway Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Vascular Permeability Endothelial Cell Migration Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Establishment Of Protein Localization Cellular Response To Leukemia Inhibitory Factor
Pathways		Inactivation, recovery and regulation of the phototransduction cascade RAS processing
Drugs		AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Eosinophil counts ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Diastolic blood pressure ( 27841878) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 27841878)
Interacting Genes		17 interacting genes: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRAS KRBA1 PTP4A3 RAP2A RRAS2 SMG9 TLX3	5 interacting genes: CDKN2A FNTA FNTB FZR1 PINX1
Entrez ID		2342	11156
HPRD ID		00608	05922
Ensembl ID		ENSG00000257365	ENSG00000184489
Uniprot IDs		A0A384MEJ5 P49356	O75365
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1R6H 1V3A 2MBC 5TSR
Enriched GO Terms of Interacting Partners?
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