COTL1 and PDE6H

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		COTL1	PDE6H
Description		coactosin like F-actin binding protein 1	phosphodiesterase 6H
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Actin Filament Plasma Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Photoreceptor Outer Segment Membrane
	Molecular Function	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding	Enzyme Inhibitor Activity Protein Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Biological_process Regulation Of Actin Filament Polymerization Defense Response To Fungus	Visual Perception Negative Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Stimulus
Pathways		Neutrophil degranulation
Drugs			Sildenafil Vardenafil
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Cocaine dependence ( 31212010) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Heel bone mineral density ( 30598549) Macular thickness ( 30535121)
Interacting Genes		7 interacting genes: ACTA1 ACTB ACTG1 ALOX5 BBS5 PDE6H TERF2IP	6 interacting genes: AGTR1 APP COTL1 GNAO1 POU6F2 PRKAB2
Entrez ID		23406	5149
HPRD ID		09482	03116
Ensembl ID		ENSG00000103187	ENSG00000139053
Uniprot IDs		A0A384MTY2 Q14019	Q13956
PDB IDs		1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
Enriched GO Terms of Interacting Partners?
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