FRAT2 and PTPN12

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		FRAT2	PTPN12
Description		FRAT regulator of WNT signaling pathway 2	protein tyrosine phosphatase non-receptor type 12
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Cytosol	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection
	Molecular Function	Molecular_function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Wnt Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane	SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs			Tiludronic acid
Diseases
GWAS		Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte count ( 32888494)	Body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte counts ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12	59 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR EIF4H ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 RUNX1 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510
Entrez ID		23401	5782
HPRD ID		05419	02513
Ensembl ID		ENSG00000181274	ENSG00000127947
Uniprot IDs		O75474	B4E105 Q05209
PDB IDs			5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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