SLC9A8 and ARFGEF2

		SLC9A8	ARFGEF2
Description		solute carrier family 9 member A8	ADP ribosylation factor guanine nucleotide exchange factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane	Golgi Membrane Golgi Apparatus Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Ion Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Potassium Ion Transmembrane Transport Anion Transmembrane Transport Proton Transmembrane Transport	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways		Sodium/Proton exchangers	Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 29212778) Early cardiac repolarization ( 31600170) Gut microbiota (beta diversity) ( 27723756) Multiple sclerosis ( 24076602) Psoriasis ( 20953189)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: ARFGEF2 MEOX2 MOCS3 TMSB4XP6	11 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A PTGIS SLC9A8
Entrez ID		23315	10564
HPRD ID		18062	09250
Ensembl ID		ENSG00000197818	ENSG00000124198
Uniprot IDs		B4DIX7 Q9Y2E8	Q59FR3 Q86TH5 Q9Y6D5
PDB IDs			3L8N 3SWV
Enriched GO Terms of Interacting Partners?
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