UBR2 and ATF3

Number of citations of the paper that reports this interaction (PubMedID 32692156)
1

Data Source:
BioGRID (protein complementation assay)

		UBR2	ATF3
Description		ubiquitin protein ligase E3 component n-recognin 2	activating transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Nucleolus CHOP-ATF3 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Negative Regulation Of Transposition Protein Ubiquitination Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Amino Acid Starvation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter In Response To Arsenic-containing Substance Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs			Pseudoephedrine
Diseases
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein level ( 29403010)	Blood cell traits (multivariate analysis) ( 31080455) Cerebral amyloid deposition (PET imaging) ( 26252872) Coronary artery disease ( 29212778) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122)
Interacting Genes		10 interacting genes: ATF3 H2AC20 H2BC8 NTAN1 NTAQ1 PKN1 SUOX UBE2B UBE2D2 UBE2H	50 interacting genes: APPL2 ATF2 ATF4 BATF BATF3 CEBPA CEBPE CEBPG CREB3 CREBBP CRK DBP DDIT3 DNMT3L DOK5 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUND KAT5 LRIF1 MAFF MAFG NEK2 NFE2L2 NFKB1 NUF2 PDX1 POLR3D SH2D1A SMAD3 SRA1 SS18L1 STAT1 STAT3 SUV39H1 TP53 TP73 UBE2I UBR1 UBR2 ZNF212
Entrez ID		23304	467
HPRD ID		09853	04395
Ensembl ID		ENSG00000024048	ENSG00000162772
Uniprot IDs		B3KXG6 Q8IWV8	P18847
PDB IDs		3NY2 3NY3 5TDA 5TDB 5TDD 5UM3
Enriched GO Terms of Interacting Partners?
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