FLT3LG and KITLG

Number of citations of the paper that reports this interaction (PubMedID 25241761)
12

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		FLT3LG	KITLG
Description		fms related receptor tyrosine kinase 3 ligand	KIT ligand
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane Lamellipodium Filopodium
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Signal Transduction Positive Regulation Of Cell Population Proliferation Embryonic Hemopoiesis	Ovarian Follicle Development Neural Crest Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Positive Regulation Of Cell Population Proliferation Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Aspartate aminotransferase levels ( 33547301) Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		4 interacting genes: FLT3 KITLG KRTAP5-9 PFN2	8 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1
Entrez ID		2323	4254
HPRD ID		02477	01698
Ensembl ID		ENSG00000090554	ENSG00000049130
Uniprot IDs		B7ZLY4 M0QYM9 P49771	A0A024RBC0 A0A024RBF5 P21583
PDB IDs		1ETE 3QS7 3QS9	1EXZ 1SCF 2E9W
Enriched GO Terms of Interacting Partners?
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