SMC5 and NSMCE2

Number of citations of the paper that reports this interaction (PubMedID 32389690)
5

Data Source:
BioGRID (biochemical, two hybrid)

		SMC5	NSMCE2
Description		structural maintenance of chromosomes 5	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Cytoplasm PML Body Nuclear Speck Cell Junction Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body PML Body Smc5-Smc6 Complex
	Molecular Function	Protein Binding ATP Binding	Protein Binding Zinc Ion Binding SUMO Transferase Activity SUMO Ligase Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Internal Peptidyl-lysine Acetylation Stem Cell Population Maintenance Chromosome Condensation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Chromosome Segregation Protein Localization To Chromosome, Centromeric Region Cellular Senescence	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protein Sumoylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence
Pathways		SUMOylation of DNA damage response and repair proteins	SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180)	Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) Body shape index ( 34021172) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: DISC1 EID3 NSMCE2 SLF2 SMN1 TK1	5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28
Entrez ID		23137	286053
HPRD ID		10241	08131
Ensembl ID		ENSG00000198887	ENSG00000156831
Uniprot IDs		Q8IY18	A0A024R9J6 E5RFJ1 Q96MF7
PDB IDs			2YU4
Enriched GO Terms of Interacting Partners?
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