FAIM2 and SLC22A2

Number of citations of the paper that reports this interaction (PubMedID 31318583)
3

Data Source:
BioGRID (protein complementation assay)

		FAIM2	SLC22A2
Description		Fas apoptotic inhibitory molecule 2	solute carrier family 22 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane Membrane Raft Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Presynapse
	Molecular Function	Protein Binding	Amine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Response To Ischemia Apoptotic Process Cerebellum Development Cerebellar Purkinje Cell Layer Development Cerebellar Granular Layer Development Cerebellar Purkinje Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Neurotransmitter Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Body Fluid Secretion Positive Regulation Of Gene Expression Organic Cation Transport Amine Transport Choline Transport Neurotransmitter Biosynthetic Process Xenobiotic Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Purine-containing Compound Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier Toxin Transport L-alpha-amino Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways			Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30643258) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat mass ( 28552196) Body mass index ( 28552196 19079260 28892062 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Breast size ( 27182965) Childhood body mass index ( 26604143) Hip circumference ( 28552196 25673412) Menarche (age at onset) ( 27182965) Obese vs. thin ( 30677029) Obesity (extreme) ( 30677029) Obsessive-compulsive disorder ( 22889921) Trunk fat mass ( 28552196) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist circumference ( 28552196 19557197) Weight ( 28552196 19079260)	Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body shape index ( 34021172) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hip circumference adjusted for BMI ( 34021172) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: EPN2 ERBB2 FAS GGT6 OS9 SLC22A2 STK11	45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 EXT2 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1
Entrez ID		23017	6582
HPRD ID		09184	04008
Ensembl ID		ENSG00000135472	ENSG00000112499
Uniprot IDs		Q9BWQ8	O15244
PDB IDs
Enriched GO Terms of Interacting Partners?
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