NT5C2 and ATP5PO

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		NT5C2	ATP5PO
Description		5'-nucleotidase, cytosolic II	ATP synthase peripheral stalk subunit OSCP
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Mitochondrial Proton-transporting ATP Synthase, Stator Stalk Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Plasma Membrane Proton-transporting ATP Synthase Complex, Catalytic Core F(1)
	Molecular Function	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding IMP 5'-nucleotidase Activity	Protein Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Allantoin Metabolic Process IMP Catabolic Process Dephosphorylation IMP Metabolic Process Adenosine Metabolic Process	ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Mitochondrial ATP Synthesis Coupled Proton Transport Proton Transmembrane Transport
Pathways		Abacavir metabolism Purine catabolism	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs		ATP Taribavirin	Artenimol
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758 27680694) Blood pressure ( 21572416 24001895 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Coronary artery disease ( 32469254 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Diastolic blood pressure ( 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980 32709000 30487518) Immature fraction of reticulocytes ( 32888494) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intracranial aneurysm ( 33199917) Mean arterial pressure ( 26390057 29403010 27618448 30487518) Mean corpuscular hemoglobin ( 32888494) Metabolically unhealthy in normal weight ( 33500527) Myocardial infarction ( 26343387) Pulse pressure ( 29403010 28739976 30487518 30578418) Red cell distribution width ( 27863252) Response to citalopram or escitalopram and depression ( 27622933) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872 23894747) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 26390057 28135244 19430483 21909115 29403010 28739976 27618447 27618452 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) White matter lesion progression ( 26451028)
Interacting Genes		11 interacting genes: ATP5PO CALM1 FXR2 GLYCTK MOB1B MOB3B MOB3C NME7 NOC4L NUDT18 SDCBP	21 interacting genes: APP CBR3 CCDC136 CEP70 ERCC6 GOLGA2 HMBOX1 KRT13 KRT15 MIPOL1 NDC80 NME6 NT5C2 PNMA1 RCAN1 TEX13A TFIP11 TRIP6 USHBP1 ZBTB14 ZNF76
Entrez ID		22978	539
HPRD ID		02686	02899
Ensembl ID		ENSG00000076685	ENSG00000241837
Uniprot IDs		A0A384MED8 A8K6K2 P49902	P48047
PDB IDs		2J2C 2JC9 2JCM 2XCV 2XCW 2XCX 2XJB 2XJC 2XJD 2XJE 2XJF 4H4B 5CQZ 5CR7 5K7Y 5L4Z 5L50 5OPK 5OPL 5OPM 5OPN 5OPO 5OPP 6DD3 6DDB 6DDC 6DDH 6DDK 6DDL 6DDO 6DDQ 6DDX 6DDY 6DDZ 6DE0 6DE1 6DE2 6DE3 6FIR 6FIS 6FIU 6FIW 6FXH
Enriched GO Terms of Interacting Partners?
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