FGFR2 and CACNA1D

Number of citations of the paper that reports this interaction (PubMedID 11292657)
9

Data Source:
HPRD (in vivo)

		FGFR2	CACNA1D
Description		fibroblast growth factor receptor 2	calcium voltage-gated channel subunit alpha1 D
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Vesicle Receptor Complex Excitatory Synapse Collagen-containing Extracellular Matrix	Plasma Membrane Voltage-gated Calcium Channel Complex Z Disc L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Endochondral Bone Growth Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Axonogenesis Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Phospholipase Activity Negative Regulation Of Keratinocyte Proliferation Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Response To Lipopolysaccharide Lacrimal Gland Development Positive Regulation Of Kinase Activity Regulation Of Osteoblast Proliferation Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Wound Healing Inner Ear Morphogenesis Odontogenesis Positive Regulation Of MAPK Cascade Cell Fate Commitment Response To Ethanol Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Lung Alveolus Development Mesodermal Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Calcium Ion Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport
Pathways		Signaling by FGFR2 amplification mutants Activated point mutants of FGFR2 Signaling by FGFR2 in disease Signaling by FGFR2 IIIa TM Signaling by FGFR2 fusions	Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Sensory processing of sound by inner hair cells of the cochlea
Drugs		Palifermin Thalidomide Heparin Sucrosofate 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Fostamatinib Erdafitinib Pemigatinib Selpercatinib Pralsetinib	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium sulfate Levomenthol Ethanol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Aranidipine Benidipine Cilnidipine Lacidipine Levamlodipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Adiponectin levels ( 24105470) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Body mass index ( 28892062) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 21263130 20872241 24143190 23354978 29059683 17529967 23535729 17529973 22951594 31757997 20453838 25956309 19330030) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor positive) ( 28864454) Breast cancer (progesterone-receptor positive) ( 28864454) Breast cancer in BRCA2 mutation carriers ( 23544012 21060860) Cancer (pleiotropy) ( 27197191) Childhood ear infection ( 27182965) Core binding factor acute myeloid leukemia ( 27903959) Coronary artery disease ( 32469254) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estrogen receptor status in breast cancer ( 27764800) Estrogen receptor status in HER2 negative breast cancer ( 27764800) High density lipoprotein cholesterol levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Magnesium levels ( 26685716) PR interval ( 32439900) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 30410027 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647 30718926) Vaginal microbiome composition (L. iners) ( 32723796) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Age at first sexual intercourse ( 27089180 34211149) Axial length ( 24144296) Blood protein levels ( 28240269) Body mass index ( 25673413) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010 25249183 30487518 30578418) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) PR interval ( 32439900) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 29403010 25249183 30487518 30578418) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)
Interacting Genes		54 interacting genes: ANOS1 APP BEX1 BEX2 CACNA1D CTDSP1 CTDSPL DUSP14 ELK4 EPHA4 ERBB2 ERRFI1 FBXO7 FGF1 FGF10 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GLCE HOXC6 ITGA5 LRRK1 MDM2 MGMT MTA3 MTMR3 NECTIN1 NEDD4 OAT PAK4 PDLIM2 PLCG1 PLSCR1 PLXNA1 PPM1A PTK2B PTPN11 PTPN12 PTPRE PTPRR RASL10B RHOBTB2 S100A14 SEC23IP SHC1 TFF1	3 interacting genes: CALB1 FGFR2 STX1A
Entrez ID		2263	776
HPRD ID		01492	00247
Ensembl ID		ENSG00000066468	ENSG00000157388
Uniprot IDs		A0A141AXF1 D2CGD1 P21802 S4R381	A0A1B0GUN6 Q01668 Q59GD8
PDB IDs		1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J23 4J95 4J96 4J97 4J98 4J99 4WV1 5EG3 5UGL 5UGX 5UHN 5UI0 6AGX 6LVK 6LVL 6V6Q 7KIA 7KIE	3LV3
Enriched GO Terms of Interacting Partners?
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