FDPS and FBN2

		FDPS	FBN2
Description		farnesyl diphosphate synthase	fibrillin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding Dimethylallyltranstransferase Activity Geranyltranstransferase Activity Protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Cholesterol Biosynthetic Process Geranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process	Anatomical Structure Morphogenesis Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Pamidronic acid Zoledronic acid Alendronic acid Ibandronate Risedronic acid Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE Incadronic acid Minodronic acid Farnesyl diphosphate Geranylgeranyl diphosphate	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Brain morphology (MOSTest) ( 32665545) Breastfeeding duration ( 25475840) Central corneal thickness ( 32528159) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 32771030) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: ABHD16A ATXN1 CREB3 EIF4ENIF1 FBN2 FGFR1 RNF19B SLC30A2 SSMEM1	22 interacting genes: CMBL CSF2 DPYSL5 DUSP5 ELN FBN1 FDPS ITGA2 LTBP1 MATN2 MFAP2 MFAP5 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SMAD2 SNRPB TRIM24 UBE2B
Entrez ID		2224	2201
HPRD ID		00606	00416
Ensembl ID		ENSG00000160752	ENSG00000138829
Uniprot IDs		A0A087X090 P14324	P35556
PDB IDs		1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K 3RYE 3S4J 4DEM 4GA3 4H5C 4H5D 4H5E 4JVJ 4KFA 4KPD 4KPJ 4KQ5 4KQS 4KQU 4L2X 4LFV 4LPG 4LPH 4N1Z 4N9U 4NFI 4NFJ 4NFK 4NG6 4NKE 4NKF 4NUA 4OGU 4P0V 4P0W 4P0X 4PVX 4PVY 4Q23 4QPF 4QXS 4RXA 4XQR 4XQS 4XQT 5CG5 5CG6 5DGM 5DGN 5DGS 5DIQ 5DJP 5DJR 5DJV 5JA0 5JUZ 5JV0 5JV1 5JV2 5KSX 5YGI 6N7Y 6N7Z 6N82 6N83 6OAG 6OAH
Enriched GO Terms of Interacting Partners?
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