FCGR3A and FCGR1A

Number of citations of the paper that reports this interaction (PubMedID 7516890)
13

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		FCGR3A	FCGR1A
Description		Fc fragment of IgG receptor IIIa	Fc fragment of IgG receptor Ia
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity IgG Binding	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Immune Response	Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Blood protein levels ( 28240269) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 30498034 23830517) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908)
Interacting Genes		20 interacting genes: APCS APP CD247 CD38 CD4 FCER1G FCGR1A FCGR2A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25	30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID		2214	2209
HPRD ID		00903	00904
Ensembl ID		ENSG00000203747	ENSG00000150337
Uniprot IDs		H0Y755 P08637	P12314
PDB IDs		3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5	3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?