EVPL and PI3

Number of citations of the paper that reports this interaction (PubMedID 8999895)
30

Data Source:
HPRD (in vivo)

		EVPL	PI3
Description		envoplakin	peptidase inhibitor 3
Image
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis
	Biological Process	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	Copulation Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Antibacterial Humoral Response Innate Immune Response
Pathways		Formation of the cornified envelope	Antimicrobial peptides Formation of the cornified envelope
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488 28240269) Malaria ( 31844061)
Interacting Genes		14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3	6 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN SRC
Entrez ID		2125	5266
HPRD ID		03352	15947
Ensembl ID		ENSG00000167880	ENSG00000124102
Uniprot IDs		B7ZLH8 K7EKI0 Q92817	P19957
PDB IDs		4QMD	1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?
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